Newsletter #8: The ETAP-Lab Psoriasis Model
The psoriasis model induced by the chronic application of imiquimod (IMI) proposed by ETAP-Lab reproducibly replicates the key markers of the pathology observed in humans: hyperproliferation of keratinocytes, hyperkeratosis and parakeratosis. At the systemic level, the strong activation of the immune system alongside the increased expression of characteristic cytokines such as IL-6, Il-17, IL-23 and TNF-alpha is also consistent with human pathology. Psoriasis is not, however, limited to these parameters classically measured in animals. Indeed, the skin discomfort induced by