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in vitro & in vivo Neurology

Since its inception, ETAP-Lab has showcased robust consistently expertise in preclinical neurology, initially focusing on in vivo models and more recently expanding into in vitro approaches. We specialize particularly such as stroke, neurodegenerative diseases featuring Alzheimer’s and Parkinson’s models, as well as psychopharmacology and cognition.

Our models by area of expertise

in vitro Models

Thromboelastography (ROTEM)
Clot lysis

in vivo Models

Distal Ischemic Stroke models
Fibrin-rich clot thrombosis model
Platelet-rich clot thrombosis model
Transient ischemic attack
Permanent ischemia

Proximal Ischemic Stroke models
Thrombo-embolic stroke: Monoclot version
Thrombo-embolic stroke: Multiclot version
Ischemia-Reperfusion (MCAo)

Hemorrhagic Stroke models
In situ infusion of heterologous blood
Intracerebral aneurisms
Cerebral injection of collagenase

FAST model
FeCl3 model

Continue on the STROKALLIANCE website

STROKE models

In vitro models

Amyloid Beta Oligomers model (rodent and HiPS cells)

Tau Oligomers model

Alpha Synuclein oligomers model

In vivo models

Early Alzheimer’s diseases model with Amyloid Beta Oligomers and aged mice

Parkinson’s disease model induced with 6-OHDA

NDD's models

Anxiety

Elevated plus Maze

Defensive burying test

Light/Dark box test

Depression

Forced Swim Test

Sucrose preference Test

Learning

Morris Water Maze

Novel Object Recognition

Neuro-pharmacokinetic (Neuro-PK)

Biodistribution study

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Our platform

Behavioural tests

Stereotaxic & micro-surgery

Imaging

Histology & Immunohistochemistry

Biological assays

In vitro pharmacology

Our R&D Projects

Bio-Diamond

The BIO-DIAMOND project stands as a pioneering pilot initiative showcasing the potential of organ-on-chip technology to expedite the market entry of drug candidates in the “discovery” and “pre-clinical” phases, specifically focusing on Alzheimer’s, Parkinson’s, and Amyotrophic Lateral Sclerosis (ALS).

The project, in collaboration with NETRI, has emerged as a winner of the “Innovations in biotherapies and bioproduction” call for projects funded by the French government as part of France 2030.

BrioFlam

This collaborative project with Plant Advanced Technologies (PAT) and the IMoPA-CNRS laboratory at the University of Lorraine aims to discover new plant-derived anti-inflammatory compounds, with a special emphasis on bryophyte group plants.

Selected by the Grand Est Region and the State, this collaborative research initiative is backed by a total budget of 1.2 million euros.

STROKTURA

STROKTURA, Stroke for the Future, aims to find innovative solutions in brain imaging applied to preclinical models of stroke, with the purpose of testing future therapies for ischemic strokes in humans. This project, led by our team of experts in collaboration with BB@C, with scientific and technical support from PhIND, ESR3P, and CYCERON, is financially supported by FEDER and the Normandy Region.