One common pathological hallmark of neurodegenerative disease (ND) is the aggregation and accumulation of misfolding proteins, resulting in neuronal dysfunction and brain damage. A growing body of literature suggests that amyloid oligomers (including tau) are the root cause of ND.  Significant investment has been made in drug development. However, no curative molecule is currently available on the market. This may be due to several factors – most notably to flawed preclinical research in which the use and outcome of animals … Continue reading Tau oligomers: a new tool for drug discovery in AD