ETAP will participate to NutrEvent 2015 on June 17 & 18 in Lille (France), represented by Pascale ROZAN and Jean-François BISSON
ETAP will participate on June 17 & 18 to NutrEvent in Lille. You can contact us for scheduling a meeting there with Pascale ROZAN or Jean-François BISSON . For more information about this meeting click here.
Shaping mycolactone for therapeutic use against inflammatory disorders
Inflammation adversely affects the health of millions of people worldwide, and there is an unmet medical need for better anti-inflammatory drugs. We evaluated the therapeutic interest of mycolactone, a polyketide-derived macrolide produced by Mycobacterium ulcerans. Bacterial production ofmycolactone in human skin causes a combination of ulcerative, analgesic, and anti-inflammatory effects. Whereas ulcer formation is mediated by the proapoptotic activity of mycolactone on skin cells via hyperactivation of Wiskott-Aldrich syndrome proteins, analgesia results from neuronal hyperpolarization via signaling through angiotensin II type 2 receptors. Mycolactone also blunts the capacity of immune