ETAP will be present to the VITAFOODS Europe 2014 in Geneva (Switzerland) on May 6 and 7 – represented by Jean-François BISSON (Scientific Director)
You can meet Dr Jean-François BISSON (Scientific Director) for any inquiry about the activities of ETAP and experimental models. For more information about this congress click here.
p-Coumaric acid activates the GABA-A receptor in vitro and is orally anxiolytic in vivo.
The increasing prevalence and social burden of subclinical anxiety in the western world represents a significant psychosocial and financial cost. Consumers are favouring a more natural and nonpharmacological approach for alleviating the effects of everyday stress and anxiety. The gamma-aminobutyric acid (GABA) receptor is the primary mediator of central inhibitory neurotransmission, and GABA-receptor agonists are well known to convey anxiolytic effects. Using an in vitro screening approach to identify naturally occurring phytochemical GABA agonists, we discovered the plant secondary metabolite