Anxiolitic and antidepressant-like effects of Garum armoricum® (GA), a blue ling finsh protein autolysate in male wistar rats
The anxiolytic- and antidepressant-like effects of Garum Armoricum® (GA), a protein autolysate from the blue ling fish, were studied in male Wistar rats using the conditioned defensive burying (CDB) and the forced swimming (FST) tests, respectively. In the CDB, all doses of GA (25, 50 and 100 mg/kg, PO) decreased the global score of anxiety and the latency of the first approach towards the probe after shock, in a similar way to diazepam (DZP) at the dose of 3 mg/kg,
The effects of Garum armoricum® (GA) on elevated-plus maze and conditioned light extinction tests in rats
Garum Armoricum® (GA), a compound rich in polyunsaturated fatty acids, free amino acids, small peptides, vitamins and minerals, was evaluated on two fear-related assays in rats. GA and diazepam (DZP) increased entries into open arms relative to placebo, as well as percentage of open arm entries in the elevated plus-maze test. In a similar fashion, all drugged groups spent more time inside the open arms and less time inside the enclosed arms. After a two-day period of conditioned avoidance learning