With more than 20 years of experience, ETAP-Lab provides Toxicology services to the biotechnology, chemical, agrochemical, dermatological, food and medical devices companies. Our studies meet the highest standards (our Toxicology Department is certified ISO 9001) and our facilities are custom built for efficiency and to ensure good ethological practices, the welfare of animals and the ethics of animal experimentation.
The objective of in vivo toxicology studies is to identify the target organs and the potentially toxic doses of the compounds tested for a living organism. Toxicity studies are carried out in compliance with the standards of the OECD and the US EPA.
Short-term toxicity studies
The aim of acute toxicity studies is to assess the effects of exposure to a high dose of a compound in young and healthy animals, usually in females. These studies can specify the dose(s) that will be used for sub-chronic and/or chronic toxicity studies. These studies can be performed in mice and/or rats.
- Acute oral toxicity (OECD 420/423/425 / US EPA 870.1100)
- Acute dermal toxicity (OECD 402 – new draft Directive no. 434 – / US EPA 870.1200)
- Determination of the maximal tolerated dose (MTD): Oral route, IV, IP, SC…
Sub-chronic and chronic toxicity studies
The aim of sub-chronic and chronic toxicity studies is to assess the effects of exposure to repeated administrations of the compounds tested at one or three doses in animals of both sexes in order to determine the maximum dose without observable harmful effects, the NOAEL, which corresponds to the highest dose of a compound that does not produce any observable harmful effect.
These studies can be performed in mice and/or rats.
- 28-day oral toxicity (OECD 407 – US EPA 870.3050)
- 90-day oral toxicity (OECD 408 – US EPA 870.3100)
- 12-month oral toxicity (OECD 452 – US EPA 870.4100)
- 21/28-day dermal toxicity (OECD 410 – US EPA 870.3200)
- 90-day dermal toxicity (OECD 411 – US EPA 870.3250)
- Carcinogenicity study (OECD 451 – US EPA 870.4200)
- Determination of the maximal total tolerated dose (MTTD) (oral route, IV, IP, SC…)