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in vitro & in vivo Neurology

Since its inception, ETAP-Lab – preclinical CRO – has demonstrated solid expertise in preclinical neurology, initially focusing on in vivo models with historical behavioral expertise, we offer efficacy models with high translational approach taking into account most risk factors. We have extended our know-how to in vitro approaches, with a broad portfolio of cellular models of Neurodegenerative diseases and proteinopathies such as Alzheimer’s and Parkinson’s disease. Our services include advanced high-content screening, bioassays & histology platform, fully-equipped with wide variety of analyzes & biomarkers. We offer a comprehensive range of solutions, from standard to customized to meet your specific needs, in the fields of Neuroscience & CNS – neurodegenerative diseases and psychopharmacology.

Our models by area of expertise

in vitro models

Protein aggregation (cell free) | Induction with AβO, TauO or αSO
Excitotoxicity* | Glutamate injuries
Oxidative stress* | H₂O₂-induced
Neurogenesis*
Synaptogenesis*
Neuroinflammation (Human iPSC Astrocyte) | Induction with AβO or Cytokine
Neurodegeneration*| Induction with AβO, TauO or αSO, or 6-OHDA

READOUTS

Diagnostic of amyloid structure | Cell viability | Neurite network | Synaptic density | Astrogliosis| Inflammation signaling pathway | Proliferation

in vivo models

READOUTS

Memory impairments | Sensorimotor deficits | Synaptic loss | Astrogliosis | Microglia activation

*Cortical Primary Neurons. Proteinopathies models in blue.

AβO for Amyloid Beta Oligomers. TauO for Tau Oligomers. αSO for Alpha Synuclein Oligomers.

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in vivo models

MOOD DISTURBANCES MODELS

Anxiety models | Induction options: Elevated plus Maze test, Defensive burying test, Light/Dark box test,

Marble burying test or Chronic mild stress induction

Depression models | Induction with Chronic mild stress induction

Learning models | Induction with Morris Water Maze test or Novel Object Recognition.

Locomotor activity | Induction with Open-field test

MOTOR DISTURBANCES MODELS

Sensorimotor assessment | Induction with Rotarod

MAIN READOUTS

Physiological monitoring & video tracking data | Sucrose preference Test | Behavioural scoring | Memoryand Motor performances assessement | Dosage in CSF, blood, brain and organs

Neuro-PharmacoKinetic (Neuro-PK) models | Delivery of a pharmacological compound. All administration routes (PO, IV, IP, IN, IT, SC).

MAIN READOUTS

Dosage in CSF, blood, brain and organs

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Our platforms

Behavioural tests

Stereotaxic & micro-surgery

in vivo Imaging

Histology & Immunohistochemistry

Biological assays

In vitro pharmacology

Our R&D Projects

Bio-Diamond

The BIO-DIAMOND project stands as a pioneering pilot initiative showcasing the potential of organ-on-chip technology to expedite the market entry of drug candidates in the “discovery” and “pre-clinical” phases, specifically focusing on Alzheimer’s, Parkinson’s, and Amyotrophic Lateral Sclerosis (ALS).

The project, in collaboration with NETRI, has emerged as a winner of the “Innovations in biotherapies and bioproduction” call for projects funded by the French government as part of France 2030.

BrioFlam

This collaborative project with Plant Advanced Technologies (PAT) and the IMoPA-CNRS laboratory at the University of Lorraine aims to discover new plant-derived anti-inflammatory compounds, with a special emphasis on bryophyte group plants.

Selected by the Grand Est Region and the State, this collaborative research initiative is backed by a total budget of 1.2 million euros.